Systematic Review of the Epidemiological Burden of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Across Europe: Current Evidence and EUROMENE Research Recommendations for Epidemiology

Estévez-López, Fernando, Mudie, Kathleen, Wang-Steverding, Xia, Bakken, Inger Johanne, Ivanovs, Andrejs, Castro-Marrero, Jesús, Nacul, Luis, Alegre, Jose, Zalewski, Paweł, Słomko, Joanna, Strand, Elin Bolle, Pheby, Derek, Shikova, Evelina, Lorusso, Lorenzo, Capelli, Enrica, Sekulic, Slobodan, Scheibenbogen, Carmen, Sepúlveda, Nuno, Murovska, Modra and Lacerda, Eliana (2020) Systematic Review of the Epidemiological Burden of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Across Europe: Current Evidence and EUROMENE Research Recommendations for Epidemiology. Journal of Clinical Medicine, 9 (5). e1557. ISSN 2077-0383

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Abstract

This review aimed at determining the prevalence and incidence of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) in Europe. We conducted a primary search in Scopus, PubMed and Web of Science for publications between 1994 and 15 June 2019 (PROSPERO: CRD42017078688). Additionally, we performed a backward-(reference lists) and forward-(citations) search of the works included in this review. Grey literature was addressed by contacting all members of the European Network on ME/CFS (EUROMENE). Independent reviewers searched, screened and selected studies, extracted data and evaluated the methodological and reporting quality. For prevalence, two studies in adults and one study in adolescents were included. Prevalence ranged from 0.1% to 2.2%. Two studies also included incidence estimates. In conclusion, studies on the prevalence and incidence of ME/CFS in Europe were scarce. Our findings point to the pressing need for well-designed and statistically powered epidemiological studies. To overcome the shortcomings of the current state-of-the-art, EUROMENE recommends that future research is better conducted in the community, reviewing the clinical history of potential cases, obtaining additional objective information (when needed) and using adequate ME/CFS case definitions; namely, the Centers for Disease Control Prevention−1994, Canadian Consensus Criteria, or Institute of Medicine criteria.

Item Type: Article
Additional Information: ** From MDPI via Jisc Publications Router ** History: accepted 19-05-2020; pub-electronic 21-05-2020. ** Licence for this article: https://creativecommons.org/licenses/by/4.0/
Keywords: central nervous system diseases, infections, muscular diseases, post-exertional malaise, virus diseases
SWORD Depositor: JISC Router
Depositing User: JISC Router
Date Deposited: 10 Jun 2020 08:20
Last Modified: 10 Jun 2020 08:20
URI: http://bucks.repository.guildhe.ac.uk/id/eprint/18008

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