p22 phox C242T Single-Nucleotide Polymorphism Inhibits Inflammatory Oxidative Damage to Endothelial Cells and Vessels

Meijles, Daniel N., Fan, Lampson M., Ghazaly, Maziah M., Howlin, Brendan, Krönke, Martin, Brooks, Gavin and Li, Jian-Mei (2016) p22 phox C242T Single-Nucleotide Polymorphism Inhibits Inflammatory Oxidative Damage to Endothelial Cells and Vessels. Circulation, 133 (24). pp. 2391-2403. ISSN 0009-7322

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Abstract

The NADPH oxidase, by generating reactive oxygen species, is involved in the pathophysiology of many cardiovascular diseases and represents a therapeutic target for the development of novel drugs. A single-nucleotide polymorphism, C242T of the p22(phox) subunit of NADPH oxidase, has been reported to be negatively associated with coronary heart disease and may predict disease prevalence. However, the underlying mechanisms remain unknown.

Item Type: Article
Keywords: NADPH oxidase, blood vessels, endothelium, genetics, inflammation, structure
Depositing User: RED Unit Admin
Date Deposited: 21 Jan 2020 11:29
Last Modified: 21 Jan 2020 11:29
URI: http://bucks.repository.guildhe.ac.uk/id/eprint/17963

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